Patient Info

PREDNISONE

PredniSONE Intensol; Sterapred DS; Sterapred

DOSING IN  ADULTS 

Generally 0.5  mg/kg/day in 2-3 divided doses FOR SHORT PERIODS in Inflammatory bowel Disease

Administer with meals to decrease gastrointestinal upset


DOSAGE FORMS
 

Tablet: 1 mg, 2.5 mg, 5 mg, 10 mg, 20 mg, 50 mg
  

SIGNIFICANT
ADVERSE REACTIONS

Weight gain
Increased appetite
Headache
Hirsutism
Diabetes mellitus
Arthralgia
Cataracts
Glaucoma
Cushing’s syndrome
Edema
Fractures
Hallucinations
Hypertension
Muscle-wasting

Prolonged use of corticosteroids may also increase the incidence of secondary infection and  mask acute infection (including fungal infections
In patients receiving high doses of systemic corticosteroids for ≥14 days, wait at least 1 month between discontinuing steroid therapy and administering dead organism vaccines.
The use of live vaccines is contraindicated in immunosuppressed patients.


CONTRAINDICATIONS
 — Hypersensitivity to prednisone or any component of the formulation; serious infections; systemic fungal infections; varicella

DRUG INTERACTIONS 

Amphotericin: Corticosteroids may increase the hypokalemic effects of amphotericin B; monitor.
Antacids: May decrease the absorption of corticosteroids; separate administration by 2 hours.
Anticholinesterases: Concurrent use may lead to severe weakness in patients with myasthenia gravis.
Antidiabetic agents: Corticosteroids may decrease the hypoglycemic effects of antidiabetic agents; monitor.
Antifungal agents (azole): May increase the serum levels/effects of corticosteroids; monitor.
Barbiturates: May decrease the levels/effects of corticosteroids.
Bile acid sequestrants: May reduce the absorption of corticosteroids; separate administration by 2 hours.
Calcium channel blockers (nondihydropyridine): May increase the serum levels/effects of corticosteroids; monitor.
Cyclosporine: Corticosteroids may increase the serum levels/effects of cyclosporine. In addition, cyclosporine may increase levels of corticosteroids.
Diuretics, potassium-wasting (loop or thiazide): Hypokalemic effects may be increased by corticosteroids; monitor.
Estrogens: May increase the serum levels/effects of corticosteroids; monitor.
Fluoroquinolones: Concurrent use may increase the risk of tendinopathies (including tendonitis and rupture), particularly in elderly patients (overall incidence rare)
Isoniazid: Serum levels/effects may be decreased by corticosteroids.
Macrolide antibiotics: May increase the serum levels/effects of corticosteroids.
Neuromuscular-blocking agents: Concurrent use with corticosteroids may increase the risk of myopathy.
Nonsteroidal anti-inflammatory drugs (NSAIDs): Concurrent use with corticosteroids may lead to an increased incidence of gastrointestinal adverse effects; use caution.
Rifamycin derivatives: May decrease the levels/effects of corticosteroids (systemic); monitor.
Salicylates: Salicylates may increase the gastrointestinal adverse effects of corticosteroids.
Warfarin: Corticosteroids may increase the anticoagulant effects of warfarin; monitor INR.

PREGNANCY IMPLICATIONS — Crosses the placenta. Available evidence suggests safe use during pregnancy.

LACTATION — Enters breast milk/compatible.