PredniSONE Intensol; Sterapred DS; Sterapred
DOSING IN ADULTS
Generally 0.5 mg/kg/day in 2-3 divided doses FOR SHORT PERIODS in Inflammatory bowel Disease
Administer with meals to decrease gastrointestinal upset
Tablet: 1 mg, 2.5 mg, 5 mg, 10 mg, 20 mg, 50 mg
SIGNIFICANT ADVERSE REACTIONS
Prolonged use of corticosteroids may also increase the incidence of secondary infection and mask acute infection (including fungal infections
In patients receiving high doses of systemic corticosteroids for ≥14 days, wait at least 1 month between discontinuing steroid therapy and administering dead organism vaccines.
The use of live vaccines is contraindicated in immunosuppressed patients.
CONTRAINDICATIONS — Hypersensitivity to prednisone or any component of the formulation; serious infections; systemic fungal infections; varicella
Amphotericin: Corticosteroids may increase the hypokalemic effects of amphotericin B; monitor.
Antacids: May decrease the absorption of corticosteroids; separate administration by 2 hours.
Anticholinesterases: Concurrent use may lead to severe weakness in patients with myasthenia gravis.
Antidiabetic agents: Corticosteroids may decrease the hypoglycemic effects of antidiabetic agents; monitor.
Antifungal agents (azole): May increase the serum levels/effects of corticosteroids; monitor.
Barbiturates: May decrease the levels/effects of corticosteroids.
Bile acid sequestrants: May reduce the absorption of corticosteroids; separate administration by 2 hours.
Calcium channel blockers (nondihydropyridine): May increase the serum levels/effects of corticosteroids; monitor.
Cyclosporine: Corticosteroids may increase the serum levels/effects of cyclosporine. In addition, cyclosporine may increase levels of corticosteroids.
Diuretics, potassium-wasting (loop or thiazide): Hypokalemic effects may be increased by corticosteroids; monitor.
Estrogens: May increase the serum levels/effects of corticosteroids; monitor.
Fluoroquinolones: Concurrent use may increase the risk of tendinopathies (including tendonitis and rupture), particularly in elderly patients (overall incidence rare)
Isoniazid: Serum levels/effects may be decreased by corticosteroids.
Macrolide antibiotics: May increase the serum levels/effects of corticosteroids.
Neuromuscular-blocking agents: Concurrent use with corticosteroids may increase the risk of myopathy.
Nonsteroidal anti-inflammatory drugs (NSAIDs): Concurrent use with corticosteroids may lead to an increased incidence of gastrointestinal adverse effects; use caution.
Rifamycin derivatives: May decrease the levels/effects of corticosteroids (systemic); monitor.
Salicylates: Salicylates may increase the gastrointestinal adverse effects of corticosteroids.
Warfarin: Corticosteroids may increase the anticoagulant effects of warfarin; monitor INR.
PREGNANCY IMPLICATIONS — Crosses the placenta. Available evidence suggests safe use during pregnancy.
LACTATION — Enters breast milk/compatible.