RANITIDINE
Zantac 150™ [OTC]; Zantac 75® [OTC]; Zantac® EFFERdose®; Zantac®
DOSING IN ADULTS
Prevention of heartburn: Zantac®75 [OTC]: 75 mg 30-60 minutes before eating food or drinking beverages which cause heartburn; maximum: 150 mg in 24 hours; do not use for more than 14 days
Erosive esophagitis: 150 mg 4 times/day; maintenance: 150 mg twice daily
Gastric ulcer:150 mg twice daily; maintenance: 150 mg once daily at bedtime
Duodenal ulcer: 150 mg twice daily, or 300 mg once daily after the evening meal or at bedtime; maintenance: 150 mg once daily at bedtime
Eradication of Helicobacter pylori: Oral: 150 mg twice daily; requires combination therapy
DOSING IN RENAL IMPAIRMENT 150 mg every 24 hours
DOSING IN HEPATIC IMPAIRMENT Adjustments are not necessary
DOSAGE FORMS
Capsule 150 mg, 300 mg
Syrup: 15 mg/mL (5 mL, 10 mL)
Zantac®: 15 mg/mL (473 mL) [contains alcohol 7.5%; peppermint flavor]
Tablet: 75 mg [OTC], 150 mg, 300 mg
Zantac®: 150 mg, 300 mg
Zantac 75®: 75 mg
Zantac 150™: 150 mg
Tablet, effervescent:
Zantac® EFFERdose®: 25 mg [contains sodium 1.33 mEq/tablet, phenylalanine 2.81 mg/tablet, and sodium benzoate]
ADMINISTRATION
EFFERdose®: Should not be chewed, swallowed whole, or dissolved on tongue: 25 mg tablet: Dissolve in at least 5 mL (1 teaspoonful) of water; wait until completely dissolved before administering
ADVERSE REACTIONS SIGNIFICANT
Dizziness
Headache
Mental confusion
Rash
Pancreatitis
Agranulocytosis
Hepatic failure
CONTRAINDICATIONS — Hypersensitivity to ranitidine or any component of the formulation
DRUG INTERACTIONS
Antifungals: Ranitidine may reduce the absorption of itraconazole or ketoconazole.
Atazanavir: Histamine H2 antagonists may decrease the absorption of atazanavir.
Cefuroxime, cefpodoxime: The absorption of some cephalosporins may be reduced by ranitidine (separate administrations times by at least 2 hours).
Warfarin: May increase or decrease prothrombin time when used concomitantly; monitor.
PREGNANCY RISK FACTOR — B
LACTATION — Enters breast milk/use caution.